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BioProcess
International
DIGITAL EDITION
ARCHIVE
BioProcess
International
CONJUGATES
September 2023
DIVERSE The Rise of Antibody–Drug Conjugates and
Related Modalities: Innovations and Partnerships
Lead the Way . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . C2
PLATFORMS Gareth Macdonald
Developers Work To Refine Platforms for
the Best Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
EXPAND THE Cheryl Scott
Manufacturing Challenges of Therapeutic
TOOLKIT Antibody–Drug Conjugates . . . . . . . . . . . . . .
BioProcess International DIGITAL EDITION ARCHIVE
BioProcess International CONJUGATES Septemb
The Rise of Antibody–Drug Conjugates and Related
mid-1970s that scientists could target medicines
A surge in research collaborations between compan
vaccine), which protects against the bacteria res
Developers Work To Refine Platforms for the Best
this featured report. To overcome those limitatio
developed during the conjugation reaction. As pre
bivalent conjugation to a bromoacetylated peptide
Manufacturing Challenges of Therapeutic Antibody–
Figure 1B: Antibody–drug conjugate (ADC) structur
Full-length antibodies can be purified using PLAT
Table 1: Antibody–drug conjugate (ADC) linker che
Figure 3: Idealized size-exclusion chromatography
Figure 4B: Example linker–toxin (LT) coupling and
Figure 6: In this generalized process flow for AD
Table 2: Analytical methods for ADC development a
new applications for conjugated antibody products
29 Nguyen TD, Bordeau BM, Balthasar JP. Mech
STRONGER AS ONE WuXi XDC - Your One-Stop Antibo