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<br /> BioProcess<br /> International<br /> DIGITAL EDITION<br /> ARCHIVE<br /> January–February 2022 | Volume 20 | Number 1–2<br /> www.bioprocessintl.com<br /> BioProcess<br /> International<br /> Covering the whole development process<br /> for the global biotechnology industry<br /> UPSTREAM<br /> PRODUCTION<br /> · Controlling PTMs in CHO Cell Culture<br /> · Analyzing Single-Use Materials for<br /> Cell Culture Operations<br /> · Building a Digital Foundation for<br /> Biomanufacturing<br /> · Navigating the Outsourcing Journey<br /> · Asian Bioprocessors Are Looking<br /> Closer to Home for Supplies<br /> • FEATURED REPORT:<br /> Antibody Derivatives<br /> Quality.<br /> Trust ours to enable yours.<br /> 10of10<br /> approved CAR-T and<br /> gene therapies use our<br /> technologies for<br /> product lot release<br /> Trust your gene therapy and vaccine development<br /> to the highest quality analytics.<br /> KƵƌƉƌŽĚƵĐƚ<a title="January-February 2022 page 1" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=1"> BioProcess International DIGITAL EDITION ARCHIVE</a> <a title="January-February 2022 page 2" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=2"> January–February 2022 | Volume 20 | Number 1–2 ww</a> <a title="January-February 2022 page 3" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=3"> Quality. Trust ours to enable yours. 10of10 </a> <a title="January-February 2022 page 4" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=4"> </a> <a title="January-February 2022 page 5" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=5"> BioProcess International Highlights . . . . . . .</a> <a title="January-February 2022 page 6" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=6"> STRONGER AS ONE One Source On</a> <a title="January-February 2022 page 7" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=7"> JANUARY–FEBRUARY 2022 www.bioprocessintl.com/eBoo</a> <a title="January-February 2022 page 8" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=8"> FROM THE EDITOR H appy 2022 to all </a> <a title="January-February 2022 page 9" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=9"> BioProcess Insider The BioProcess Insider digital</a> <a title="January-February 2022 page 10" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=10"> BPINSIDER Although BIO-ISAC cannot comment o</a> <a title="January-February 2022 page 11" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=11"> FOCUS ON... BUSINESS Bioprocessing Facil</a> <a title="January-February 2022 page 12" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=12"> The global biopharmaceutical industry emphas</a> <a title="January-February 2022 page 13" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=13"> Table 1: Global comparison of biomanufacturing ca</a> <a title="January-February 2022 page 14" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=14"> W O N ZETA A S U I N E T H</a> <a title="January-February 2022 page 15" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=15"> FOCUS ON... OUTSOURCING In Search of a C</a> <a title="January-February 2022 page 16" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=16"> Process characterization and development EXPERTIS</a> <a title="January-February 2022 page 17" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=17"> Table 2: The relationship between a startup bioph</a> <a title="January-February 2022 page 18" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=18"> Knowledge and Material Transfer: Early in t</a> <a title="January-February 2022 page 19" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=19"> BIOPROCESS TECHNICAL Posttranslational Modific</a> <a title="January-February 2022 page 20" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=20"> bound and cleared by mannose receptors (14), resu</a> <a title="January-February 2022 page 21" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=21"> (33). Culture conditions such as temperature, pH,</a> <a title="January-February 2022 page 22" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=22"> significantly. Currently, the general practice is</a> <a title="January-February 2022 page 23" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=23"> Enzyme Microbial Technol. 103, 2017: 53–58; https</a> <a title="January-February 2022 page 24" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=24"> +RZ'R<RX%DODQFH7RGD\ V'HPDQGVb:LWKb 7RPRUURZ</a> <a title="January-February 2022 page 25" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=25"> BIOPROCESS TECHNICAL Analyzing Single-Use Polym</a> <a title="January-February 2022 page 26" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=26"> (A) Grade 0 — none Fresh medium </a> <a title="January-February 2022 page 27" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=27"> Figure 2: Graph shows qualitative morphological g</a> <a title="January-February 2022 page 28" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=28"> Figure 4: Sf9 growth kinetics (n = 3) were charte</a> <a title="January-February 2022 page 29" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=29"> Table 3: Summarized results from all cytotoxicity</a> <a title="January-February 2022 page 30" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=30"> From Concept to Commercialization With nearly t</a> <a title="January-February 2022 page 31" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=31"> We tested both PP extracts with the particles, an</a> <a title="January-February 2022 page 32" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=32"> ARE YOU LOOKING FOR EXPERTS IN MICROBIAL PRODUC</a> <a title="January-February 2022 page 33" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=33"> false results. We reached an increased adherence </a> <a title="January-February 2022 page 34" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=34"> Think BTEC for biopharma professional development</a> <a title="January-February 2022 page 35" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=35"> The tests cannot explain the reasons for an occur</a> <a title="January-February 2022 page 36" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=36"> 19 Weber W, Fussenegger M. Insect Cell- Bas</a> <a title="January-February 2022 page 37" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=37"> BIOPROCESS TECHNICAL Establishing a Digital Pla</a> <a title="January-February 2022 page 38" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=38"> GLOSSARY An application programming interface (AP</a> <a title="January-February 2022 page 39" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=39"> Figure 3: Block diagram of data flow for a data s</a> <a title="January-February 2022 page 40" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=40"> PLATFORM FOUNDATION For the case study below, dat</a> <a title="January-February 2022 page 41" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=41"> Figure 7: Diagnosis of process excursions with co</a> <a title="January-February 2022 page 42" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=42"> LESSONS LEARNED FROM PLATFORM DEVELOPMENT Designi</a> <a title="January-February 2022 page 43" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=43"> SUPPLIER SIDE High-Yield Production of rAd26-S </a> <a title="January-February 2022 page 44" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=44"> characterized at ProBioGen) that was adapted to a</a> <a title="January-February 2022 page 45" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=45"> Figure 2: Off-line measurement of cell viability </a> <a title="January-February 2022 page 46" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=46"> maintain cell growth for HEK293 cells (8). After </a> <a title="January-February 2022 page 47" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=47"> SUPPLIER SIDE Gain Control of Culture Conditions</a> <a title="January-February 2022 page 48" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=48"> Figure 3: iPSCs cultured with an FGF2-DISC stain </a> <a title="January-February 2022 page 49" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=49"> ASK THE EXPERT A Scalable Platform for Prod</a> <a title="January-February 2022 page 50" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=50"> ASK THE EXPERT Bolstering Manufacturing Capacity</a> <a title="January-February 2022 page 51" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=51"> ASK THE EXPERT Scale-Up Success for Cell Cultur</a> <a title="January-February 2022 page 52" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=52"> ASK THE EXPERT Optimized Cell Line Development f</a> <a title="January-February 2022 page 53" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=53"> ASK THE EXPERT A Platform for Purifica</a> <a title="January-February 2022 page 54" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=54"> ASK THE EXPERT Rapid Determination of AAV Capsid</a> <a title="January-February 2022 page 55" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=55"> ELU·CIDA·TION An Ethical Option for Shelved Drugs</a> <a title="January-February 2022 page 56" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=56"> Sixteen-Test Cell Culture Analyzer with Autosampl</a> <a title="January-February 2022 page 57" href="https://secure.viewer.zmags.com/publication/c5e6cfeb?page=57"> DELIVERING HIGH YIELDING CELL LINES IS SCIENCE. </a>