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<br /> BioProcess<br /> International<br /> DIGITAL EDITION<br /> ARCHIVE<br /> September 2022 | Volume 20 | Number 9<br /> www.bioprocessintl.com<br /> BioProcess<br /> International<br /> Covering the whole development process<br /> for the global biotechnology industry<br /> UPSTREAM<br /> PRODUCTION<br /> · Raman Spectroscopy for Upstream PAT<br /> · 20 Years of Upstream Advances, Part 2<br /> · Partnerships in Allogeneic Cell Therapy<br /> · The Relationship Between Quality-Risk<br /> and Knowledge Management<br /> · Applications for Synthetic Biology<br /> · Methods to Derive Mesenchymal<br /> Stromal Cells from Umbilical Cords<br /> • FEATURED REPORT:<br /> Process Monitoring and Control<br /> Quality.<br /> Trust ours to enable yours.<br /> 10of10<br /> approved CAR-T and<br /> gene therapies use our<br /> technologies for<br /> product lot release<br /> Trust your gene therapy and vaccine development<br /> to the highest<a title="September 2022 page 1" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=1"> BioProcess International DIGITAL EDITION ARCHIVE</a> <a title="September 2022 page 2" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=2"> September 2022 | Volume 20 | Number 9 www.bioproc</a> <a title="September 2022 page 3" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=3"> Quality. Trust ours to enable yours. 10of10 </a> <a title="September 2022 page 4" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=4"> </a> <a title="September 2022 page 5" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=5"> BioProcess International Highlights . . . . . . .</a> <a title="September 2022 page 6" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=6"> STRONGER AS ONE One Source WuXi XDC - </a> <a title="September 2022 page 7" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=7"> SEPTEMBER 2022 www.bioprocessintl.com/eBooks Our</a> <a title="September 2022 page 8" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=8"> SNAP AND PRODUCE. With the ease of operation of</a> <a title="September 2022 page 9" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=9"> FROM THE EDITOR J ust coming off our bi</a> <a title="September 2022 page 10" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=10"> BioProcess Insider The BioProcess Insider digital</a> <a title="September 2022 page 11" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=11"> BPINSIDER adoption to be achieved by 2030. That o</a> <a title="September 2022 page 12" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=12"> EMERGING THERAPIES BPI THEATER Improvements an</a> <a title="September 2022 page 13" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=13"> BPI THEATER EMERGING THERAPIES The Future of A</a> <a title="September 2022 page 14" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=14"> FOCUS ON... COMPLIANCE Building a Solid </a> <a title="September 2022 page 15" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=15"> Figure 2: Knowledge management and quality risk m</a> <a title="September 2022 page 16" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=16"> quality product are clear. But adoption of KM in </a> <a title="September 2022 page 17" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=17"> Figure 6: The risk–knowledge infinity cycle as ap</a> <a title="September 2022 page 18" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=18"> Accelerate Your Upstream Process Development with</a> <a title="September 2022 page 19" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=19"> Figure 7: Knowledge management process model (ada</a> <a title="September 2022 page 20" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=20"> Look critically at the knowledge captured du</a> <a title="September 2022 page 21" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=21"> 20 YEARS OF BPI Hardware, Software, and Wet</a> <a title="September 2022 page 22" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=22"> Unlike ZFNs and TALENs before it, the CRISP</a> <a title="September 2022 page 23" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=23"> nitrogen tanks. To mitigate risks that could comp</a> <a title="September 2022 page 24" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=24"> Process </a> <a title="September 2022 page 25" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=25"> ADVANCES RELATED TO CELL-THERAPY SYSTEMS A key di</a> <a title="September 2022 page 26" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=26"> exchange of groundbreaking information and knowle</a> <a title="September 2022 page 27" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=27"> FOCUS ON... LOGISTICS Future Supply-Chain</a> <a title="September 2022 page 28" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=28"> As an allogeneic cell therapy advances to higher-</a> <a title="September 2022 page 29" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=29"> Because donor starting material can be used to ma</a> <a title="September 2022 page 30" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=30"> BIOPROCESS INTERNATIONAL IS CELEBRATING OUR 20TH </a> <a title="September 2022 page 31" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=31"> BIOPROCESS TECHNICAL Synthetic Biology for Ada</a> <a title="September 2022 page 32" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=32"> established a novel hypoxia-responding cell syste</a> <a title="September 2022 page 33" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=33"> Phosphorylated NFAT5 enters nuclei and activates </a> <a title="September 2022 page 34" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=34"> Invites you to become the HERO J</a> <a title="September 2022 page 35" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=35"> 12 Huang YM, et al. Maximizing Productivity</a> <a title="September 2022 page 36" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=36"> An integrated end-to-end solution for the glob</a> <a title="September 2022 page 37" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=37"> BIOPROCESS TECHNICAL Raman Spectrometric PAT Mo</a> <a title="September 2022 page 38" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=38"> to larger process volumes. Noncontact measurement</a> <a title="September 2022 page 39" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=39"> Figure 4: Raw spectral data from the Ambr and 10-</a> <a title="September 2022 page 40" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=40"> YOUR THERAPEUTIC Microbial-based Large Molecu</a> <a title="September 2022 page 41" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=41"> Figure 5: Comparing observed and predicted plots </a> <a title="September 2022 page 42" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=42"> </a> <a title="September 2022 page 43" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=43"> BIOPROCESS TECHNICAL Deriving Mesenchymal Strom</a> <a title="September 2022 page 44" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=44"> Figure 1: Umbilical cord lining and Wharton's jel</a> <a title="September 2022 page 45" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=45"> Figure 2: Morphological differences were observed</a> <a title="September 2022 page 46" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=46"> We Meet Your Single Use Process Monitorin</a> <a title="September 2022 page 47" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=47"> PRODUCT PREVIEW - PLANNED AVAILABILITY EARLY 2023</a> <a title="September 2022 page 48" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=48"> Figure 3: (LEFT) To compare mean ± SD population </a> <a title="September 2022 page 49" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=49"> Figure 4: To determine the median fluorescence in</a> <a title="September 2022 page 50" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=50"> ATCC cGMP & cGTP Cell Banking and cGMP Bioreposit</a> <a title="September 2022 page 51" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=51"> Figure 5: Potency and genetic stability of cultur</a> <a title="September 2022 page 52" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=52"> </a> <a title="September 2022 page 53" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=53"> Figure 6: Secreted proteins from cells cultured a</a> <a title="September 2022 page 54" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=54"> gov, 2020; https://ClinicalTrials.gov/show/ NCT04</a> <a title="September 2022 page 55" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=55"> BIOPROCESS TECHNICAL Opportunities in the Field</a> <a title="September 2022 page 56" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=56"> culture media, host cell proteins, DNA, monoclona</a> <a title="September 2022 page 57" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=57"> Figure 2: Control of host-cell impurities Delete</a> <a title="September 2022 page 58" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=58"> </a> <a title="September 2022 page 59" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=59"> DISCLOSURES Probiomed S.A. de C.V. develops, manu</a> <a title="September 2022 page 60" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=60"> </a> <a title="September 2022 page 61" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=61"> SUPPLIER SIDE A Plug-and-Produce GMP Plant for C</a> <a title="September 2022 page 62" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=62"> and liquids through sterile and fully enclosed tu</a> <a title="September 2022 page 63" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=63"> Figure 1A: Layout of the CliniMACS cell factory i</a> <a title="September 2022 page 64" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=64"> standardizes a central manufacturing process and </a> <a title="September 2022 page 65" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=65"> SUPPLIER SIDE Overcoming Challenges in Viral Vect</a> <a title="September 2022 page 66" href="https://secure.viewer.zmags.com/publication/ec5ef2b9?page=66"> maturity. 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