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<br /> BioProcess<br /> International<br /> DIGITAL EDITION<br /> ARCHIVE<br /> BioProcess<br /> International<br /> SPECIAL REPORT<br /> Host Cell Protein Analysis<br /> Immunoassays and Orthogonal Characterization<br /> By Antibody Affinity Extraction and<br /> Mass Spectrometry Methods<br /> Host Cell Protein Analysis<br /> Immunoassays and Orthogonal Characterization<br /> By Antibody Affinity Extraction and<br /> Mass Spectrometry Methods<br /> Alla Zilberman, Kerry Wooding, Jacob Stubbs, Jared Isaac, and Eric Bishop<br /> H<br /> ost cell proteins (HCPs) constitute a major<br /> group of process-related impurities in<br /> biological drugs produced using cell culture<br /> technology. HCPs are produced inadvertently<br /> during the expression of recombinant<br /> biopharmaceuticals and secreted from host cells in<br /> response to cell stress and/or<a title="September 2022 - Special Report - Cygnus page 1" href="https://secure.viewer.zmags.com/publication/a1e5fb38?page=1"> BioProcess International DIGITAL EDITION ARCHIVE</a> <a title="September 2022 - Special Report - Cygnus page 2" href="https://secure.viewer.zmags.com/publication/a1e5fb38?page=2"> BioProcess International SPECIAL REPORT Host</a> <a title="September 2022 - Special Report - Cygnus page 3" href="https://secure.viewer.zmags.com/publication/a1e5fb38?page=3"> Host Cell Protein Analysis Immunoassays and Orth</a> <a title="September 2022 - Special Report - Cygnus page 4" href="https://secure.viewer.zmags.com/publication/a1e5fb38?page=4"> Figure 2: Antibody coverage by AAE chromatography</a> <a title="September 2022 - Special Report - Cygnus page 5" href="https://secure.viewer.zmags.com/publication/a1e5fb38?page=5"> Figure 4A: AAE method with 2D-PAGE/silver stain d</a> <a title="September 2022 - Special Report - Cygnus page 6" href="https://secure.viewer.zmags.com/publication/a1e5fb38?page=6"> Figure 5B: Virtual two-dimensional gel of a harve</a> <a title="September 2022 - Special Report - Cygnus page 7" href="https://secure.viewer.zmags.com/publication/a1e5fb38?page=7"> Figure 8: Fold enrichment of selected CHO HCPs </a> <a title="September 2022 - Special Report - Cygnus page 8" href="https://secure.viewer.zmags.com/publication/a1e5fb38?page=8"> Figure 11: Integration of advanced orthogonal met</a> <a title="September 2022 - Special Report - Cygnus page 9" href="https://secure.viewer.zmags.com/publication/a1e5fb38?page=9"> Boost your Host Cell Protein Analytics Help ensur</a>