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<br /> GASTROENTEROLOGY<br /> ISSN 2054-6203 Vol 7.1 • December 2018 • europeanmedical-journal.com<br /> INSIDE<br /> Review of<br /> UEG WEEK 2018<br /> Vienna, Austria<br /> Contents<br /> EDITORIAL BOARD 4<br /> WELCOME 7<br /> FOREWORD 9<br /> 01 CONGRESS REVIEW<br /> Review of UEG Week 2018, held in Vienna, Austria, 20th–24th 12<br /> October 2018<br /> BUYER'S GUIDE 28<br /> 02 INTERVIEWS WITH EMJ GASTROENTEROLOGY EDITORIAL BOARD<br /> Prof Oliver Grundmann <a title="EMJ Gastroenterology 7.1 2018 page 1" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=1"> GASTROENTEROLOGY ISSN 2054-6203 </a> <a title="EMJ Gastroenterology 7.1 2018 page 2" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=2"> Contents EDITORIAL BOARD </a> <a title="EMJ Gastroenterology 7.1 2018 page 3" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=3"> "On behalf of the EMJ team, I am proud to </a> <a title="EMJ Gastroenterology 7.1 2018 page 4" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=4"> Editorial Board Editor-in-Chief Dr Sorin T. Barbu</a> <a title="EMJ Gastroenterology 7.1 2018 page 5" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=5"> Aims and Scope The European Medical Journal (EMJ)</a> <a title="EMJ Gastroenterology 7.1 2018 page 6" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=6"> EMJ Gastroenterol. Chief Executive Officer Spence</a> <a title="EMJ Gastroenterology 7.1 2018 page 7" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=7"> Welcome On behalf of the EMJ team, I am p</a> <a title="EMJ Gastroenterology 7.1 2018 page 8" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=8"> Share your knowledge with the world. </a> <a title="EMJ Gastroenterology 7.1 2018 page 9" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=9"> Foreword Dear colleagues and friends of gastroent</a> <a title="EMJ Gastroenterology 7.1 2018 page 10" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=10"> Available now.</a> <a title="EMJ Gastroenterology 7.1 2018 page 11" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=11"> Inside this eJournal: Congress Review + Review</a> <a title="EMJ Gastroenterology 7.1 2018 page 12" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=12"> </a> <a title="EMJ Gastroenterology 7.1 2018 page 13" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=13"> Congress Review Review of the 26th</a> <a title="EMJ Gastroenterology 7.1 2018 page 14" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=14"> > The exhibition space spanned a vast 5,084 m2, w</a> <a title="EMJ Gastroenterology 7.1 2018 page 15" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=15"> More Screening Required for Young-Onset Colorecta</a> <a title="EMJ Gastroenterology 7.1 2018 page 16" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=16"> many European screening programmes are only avail</a> <a title="EMJ Gastroenterology 7.1 2018 page 17" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=17"> The researchers enrolled 46 patients wi</a> <a title="EMJ Gastroenterology 7.1 2018 page 18" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=18"> Link Between Black Death and Crohn’s Disease Reve</a> <a title="EMJ Gastroenterology 7.1 2018 page 19" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=19"> an extent that, even now, is only just becoming f</a> <a title="EMJ Gastroenterology 7.1 2018 page 20" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=20"> 20 GASTROENTEROLOGY • December 2018 </a> <a title="EMJ Gastroenterology 7.1 2018 page 21" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=21"> Austria Center Vienna Home of UEG Week 2018 </a> <a title="EMJ Gastroenterology 7.1 2018 page 22" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=22"> This year, the awards were split between re</a> <a title="EMJ Gastroenterology 7.1 2018 page 23" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=23"> Gene Expression Analysis in Inflammatory Bowel Dis</a> <a title="EMJ Gastroenterology 7.1 2018 page 24" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=24"> Dr Nicolien Schepers, who presented the</a> <a title="EMJ Gastroenterology 7.1 2018 page 25" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=25"> in many different ways,” she commented.</a> <a title="EMJ Gastroenterology 7.1 2018 page 26" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=26"> Remarkable leader and UEG President 2012- 20</a> <a title="EMJ Gastroenterology 7.1 2018 page 27" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=27"> The first question the experts were asked was whet</a> <a title="EMJ Gastroenterology 7.1 2018 page 28" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=28"> Buyer's Guide > 3-D MATRIX > 3D SYSTEMS SIMBIONIX</a> <a title="EMJ Gastroenterology 7.1 2018 page 29" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=29"> > MEDI-GLOBE GMBH/ ENDO-FLEX GMBH > MEDITALIA</a> <a title="EMJ Gastroenterology 7.1 2018 page 30" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=30"> Interviews Delve into the minds of our esteemed</a> <a title="EMJ Gastroenterology 7.1 2018 page 31" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=31"> Some of your medical training took place in Münst</a> <a title="EMJ Gastroenterology 7.1 2018 page 32" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=32"> standards of care. Furthermore, it allows clinica</a> <a title="EMJ Gastroenterology 7.1 2018 page 33" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=33"> healthcare providers to optimise treatmen</a> <a title="EMJ Gastroenterology 7.1 2018 page 34" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=34"> Dr Christoph Gubler  University Hospital Zurich, </a> <a title="EMJ Gastroenterology 7.1 2018 page 35" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=35"> negative pressure in the cavities. Sponges have t</a> <a title="EMJ Gastroenterology 7.1 2018 page 36" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=36"> in the field and the scope of specialisatio</a> <a title="EMJ Gastroenterology 7.1 2018 page 37" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=37"> using coronary artery calcification as a</a> <a title="EMJ Gastroenterology 7.1 2018 page 38" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=38"> describe as ‘mini impromptu journal clubs’, </a> <a title="EMJ Gastroenterology 7.1 2018 page 39" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=39"> More of a visual learner? </a> <a title="EMJ Gastroenterology 7.1 2018 page 40" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=40"> A Worldwide Perspective on Diagnosis and Mana</a> <a title="EMJ Gastroenterology 7.1 2018 page 41" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=41"> diversity (dysbiosis) may adversely influence colo</a> <a title="EMJ Gastroenterology 7.1 2018 page 42" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=42"> Diverticulosis Diverticular disease </a> <a title="EMJ Gastroenterology 7.1 2018 page 43" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=43"> colonic segments, as well as genetic and dietary </a> <a title="EMJ Gastroenterology 7.1 2018 page 44" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=44"> abdominal pain or tenderness during inpatient car</a> <a title="EMJ Gastroenterology 7.1 2018 page 45" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=45"> Role of Rifaximin in the Manage</a> <a title="EMJ Gastroenterology 7.1 2018 page 46" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=46"> In the TARGET3 study,53 in which patients with IB</a> <a title="EMJ Gastroenterology 7.1 2018 page 47" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=47"> interdisciplinary consensus on diagnostics and tr</a> <a title="EMJ Gastroenterology 7.1 2018 page 48" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=48"> Colorectal Dis. 2003;18(1):55-62. 50. Colecchia </a> <a title="EMJ Gastroenterology 7.1 2018 page 49" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=49"> Interact with us on social media. </a> <a title="EMJ Gastroenterology 7.1 2018 page 50" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=50"> The Emerging Treatment Landscape </a> <a title="EMJ Gastroenterology 7.1 2018 page 51" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=51"> Citation: EMJ Gastroenterol.</a> <a title="EMJ Gastroenterology 7.1 2018 page 52" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=52"> Table 1: Approaches to address unmet needs in infl</a> <a title="EMJ Gastroenterology 7.1 2018 page 53" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=53"> phase of disease, is essential. During this phase</a> <a title="EMJ Gastroenterology 7.1 2018 page 54" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=54"> Table 2: Approved adalimumab and infliximab biosim</a> <a title="EMJ Gastroenterology 7.1 2018 page 55" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=55"> The results of a survey conducted by the E</a> <a title="EMJ Gastroenterology 7.1 2018 page 56" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=56"> Tailored information, including permitted Conditi</a> <a title="EMJ Gastroenterology 7.1 2018 page 57" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=57"> in inflammatory bowel disease and 24. othe</a> <a title="EMJ Gastroenterology 7.1 2018 page 58" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=58"> Are We Ready to Change the Course of Inflammat</a> <a title="EMJ Gastroenterology 7.1 2018 page 59" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=59"> Meeting Summary The objectives of the symposium w</a> <a title="EMJ Gastroenterology 7.1 2018 page 60" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=60"> Early initiation of disease-modifying age</a> <a title="EMJ Gastroenterology 7.1 2018 page 61" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=61"> The key concept in CD management for the next dec</a> <a title="EMJ Gastroenterology 7.1 2018 page 62" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=62"> protein (CRP) and faecal calprotectin were n</a> <a title="EMJ Gastroenterology 7.1 2018 page 63" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=63"> from endoscopy. Treatment is initiated and, </a> <a title="EMJ Gastroenterology 7.1 2018 page 64" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=64"> Case 2 was asymptomatic, but the calprotectin lev</a> <a title="EMJ Gastroenterology 7.1 2018 page 65" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=65"> Disease duration prior to initiation of treatment</a> <a title="EMJ Gastroenterology 7.1 2018 page 66" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=66"> diseases. Early intervention and personalised ris</a> <a title="EMJ Gastroenterology 7.1 2018 page 67" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=67"> </a> <a title="EMJ Gastroenterology 7.1 2018 page 68" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=68"> Abstract Reviews Discover the latest research a</a> <a title="EMJ Gastroenterology 7.1 2018 page 69" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=69"> patients is of potential harm to the intestine. I</a> <a title="EMJ Gastroenterology 7.1 2018 page 70" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=70"> References 1. Cohen JE. Human population: Th</a> <a title="EMJ Gastroenterology 7.1 2018 page 71" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=71"> captured. The clinical response was assessed</a> <a title="EMJ Gastroenterology 7.1 2018 page 72" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=72"> References 1. Siegel RL et al. Cancer statis</a> <a title="EMJ Gastroenterology 7.1 2018 page 73" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=73"> Table 1: Independent predictors of hepatocellular</a> <a title="EMJ Gastroenterology 7.1 2018 page 74" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=74"> current antiviral therapy. J Hepatol. 2015;62(4):</a> <a title="EMJ Gastroenterology 7.1 2018 page 75" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=75"> using antibodies against SA100A4 and GPC3 on the </a> <a title="EMJ Gastroenterology 7.1 2018 page 76" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=76"> Bowel Preparation for Small Bowel Ca</a> <a title="EMJ Gastroenterology 7.1 2018 page 77" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=77"> examination was well-tolerated, safe, and di</a> <a title="EMJ Gastroenterology 7.1 2018 page 78" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=78"> standardised balloon expulsion test;5 in mos</a> <a title="EMJ Gastroenterology 7.1 2018 page 79" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=79"> common practice.1 However, recent studies</a> <a title="EMJ Gastroenterology 7.1 2018 page 80" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=80"> Conversely, as shown in this study, many cases of</a> <a title="EMJ Gastroenterology 7.1 2018 page 81" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=81"> lesion found using the Portsmouth protocol, </a> <a title="EMJ Gastroenterology 7.1 2018 page 82" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=82"> Mechanisms Underlying Chemotherapy-Associated </a> <a title="EMJ Gastroenterology 7.1 2018 page 83" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=83"> is a key factor behind gastrointestinal toxicity </a> <a title="EMJ Gastroenterology 7.1 2018 page 84" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=84"> INITIATION GENERATION OF SIGNALS SIGNAL AMPLIFIC</a> <a title="EMJ Gastroenterology 7.1 2018 page 85" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=85"> in preventing mucositis development.1</a> <a title="EMJ Gastroenterology 7.1 2018 page 86" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=86"> with irinotecan. Treatment of mice with an </a> <a title="EMJ Gastroenterology 7.1 2018 page 87" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=87"> was markedly increased in irinotecan-treated </a> <a title="EMJ Gastroenterology 7.1 2018 page 88" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=88"> development.33,53 TLR4 expression in the gut</a> <a title="EMJ Gastroenterology 7.1 2018 page 89" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=89"> Table 1: Therapeutic targets that have been teste</a> <a title="EMJ Gastroenterology 7.1 2018 page 90" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=90"> 6. Sonis ST. New thoughts on the </a> <a title="EMJ Gastroenterology 7.1 2018 page 91" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=91"> associated symptomatic stomatitis: Role of Herpes</a> <a title="EMJ Gastroenterology 7.1 2018 page 92" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=92"> Adenoma and Malignant Colorectal Polyp: </a> <a title="EMJ Gastroenterology 7.1 2018 page 93" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=93"> group, with the prevalence increasing with age.5 </a> <a title="EMJ Gastroenterology 7.1 2018 page 94" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=94"> A Figure 1A: Features of low-grade epithelial dy</a> <a title="EMJ Gastroenterology 7.1 2018 page 95" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=95"> Levene et al.11 conducted a study including 235 a</a> <a title="EMJ Gastroenterology 7.1 2018 page 96" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=96"> HIGH-RISK HISTOLOGICAL FACTORS FOR REGIONAL AND D</a> <a title="EMJ Gastroenterology 7.1 2018 page 97" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=97"> important in predicting outcome. For example, Hag</a> <a title="EMJ Gastroenterology 7.1 2018 page 98" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=98"> define budding, including the use of immunostains;</a> <a title="EMJ Gastroenterology 7.1 2018 page 99" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=99"> Figure 2: The RCPath dataset for reporting of loc</a> <a title="EMJ Gastroenterology 7.1 2018 page 100" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=100"> The Recognition of Muscularis Mucosa in Invasive </a> <a title="EMJ Gastroenterology 7.1 2018 page 101" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=101"> > Mucosal prolapse changes often present. > Absen</a> <a title="EMJ Gastroenterology 7.1 2018 page 102" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=102"> colorectal cancer. Gastroenterology. 2012;143(3):</a> <a title="EMJ Gastroenterology 7.1 2018 page 103" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=103"> Non-Cardiac Chest Pain: A Review of Environmental</a> <a title="EMJ Gastroenterology 7.1 2018 page 104" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=104"> a broad overview of biomarkers of GORD-associated</a> <a title="EMJ Gastroenterology 7.1 2018 page 105" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=105"> systematic reviews, or clinical s</a> <a title="EMJ Gastroenterology 7.1 2018 page 106" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=106"> Differential diagnosis Gastr o intestinal</a> <a title="EMJ Gastroenterology 7.1 2018 page 107" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=107"> visceral pleura receptors that are connected</a> <a title="EMJ Gastroenterology 7.1 2018 page 108" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=108"> Table 1: Biomarkers of non-cardiac chest pain due</a> <a title="EMJ Gastroenterology 7.1 2018 page 109" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=109"> Table 1 continued. Study Country Population</a> <a title="EMJ Gastroenterology 7.1 2018 page 110" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=110"> Elevated levels of matrix-metalloproteinase</a> <a title="EMJ Gastroenterology 7.1 2018 page 111" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=111"> FDNY firefighters to determine its potential t</a> <a title="EMJ Gastroenterology 7.1 2018 page 112" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=112"> 30. Nolan A et al. MMP-2 and TIMP-1 </a> <a title="EMJ Gastroenterology 7.1 2018 page 113" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=113"> Pathology and Pathogenesis of Radiation B</a> <a title="EMJ Gastroenterology 7.1 2018 page 114" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=114"> RBD results from therapy-induced damage t</a> <a title="EMJ Gastroenterology 7.1 2018 page 115" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=115"> estimated that the majority of patients wil</a> <a title="EMJ Gastroenterology 7.1 2018 page 116" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=116"> thus aggravating the disease. The timing of</a> <a title="EMJ Gastroenterology 7.1 2018 page 117" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=117"> phases depending on the tissue type that is predo</a> <a title="EMJ Gastroenterology 7.1 2018 page 118" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=118"> A B Figure 2: A) Crypt distortion and fibrosis of</a> <a title="EMJ Gastroenterology 7.1 2018 page 119" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=119"> Clin Oncol (R Coll Radiol). 2011;23(8):552-7. 7. </a> <a title="EMJ Gastroenterology 7.1 2018 page 120" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=120"> Prevention of Infantile Colic Using Probiotics </a> <a title="EMJ Gastroenterology 7.1 2018 page 121" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=121"> theories, such as inadequate maternal–infant </a> <a title="EMJ Gastroenterology 7.1 2018 page 122" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=122"> An adult human intestine contains about</a> <a title="EMJ Gastroenterology 7.1 2018 page 123" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=123"> Hippocampus Amygdala Emotion Stress Limbic syst</a> <a title="EMJ Gastroenterology 7.1 2018 page 124" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=124"> Table 1: Comparison of studies examining the use </a> <a title="EMJ Gastroenterology 7.1 2018 page 125" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=125"> Day 7. At the end of 30 days, treatment success w</a> <a title="EMJ Gastroenterology 7.1 2018 page 126" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=126"> In the deficit of other efficacious treatmen</a> <a title="EMJ Gastroenterology 7.1 2018 page 127" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=127"> 42. Carabotti M et al. The gut-brain </a> <a title="EMJ Gastroenterology 7.1 2018 page 128" href="https://secure.viewer.zmags.com/publication/72ffdb6c?page=128"> Never miss an update again. J</a>