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Zmags
FEATURED REPORT
Vaccines
New Pathways to
Engaging the
Immune System
MARCH 2025
01 Opportunities and Obstacles for Personalized
Cancer Vaccines
Ilona Baraniak-Lang and Anna-Lena Amend
06 Translating Transfusion-Medicine Technology
to Cancer-Vaccine Manufacturing: A Novel
Immunization Approach Based on Inactivated
Autologous Tumor Cells
Brian Gazaille with Raymond P. Goodrich
12 $GYDQFLQJ*HQH0RGLȴHGΖQDFWLYDWHG
HIV-1 Vaccines Through Clinical Studies:
Novel Approaches Merit Specialized
Manufacturing Capabilities
Brian Gazaille with Eunsil Choi and
Eric Le Forestier
18 Bottlenecks in RNA Delivery:
Optimization of LNP
Delivery Systems
Dan Peer
Cell Culture
Increased consistency.
FEATURED REPORT Vaccines New Pathways to En
Cell Culture Increased consistency. Accelerat
Opportunities and Obstacles for Personalized Canc
Lipid nanoparticle cancer vaccine delivery system
models exist to investigate bioactivity of person
disease and its associated side effects. Such spe
14 Oladejo M, Paulishak W, Wood L. Synergis
Translating Transfusion-Medicine Technology to Ca
Neoantigen Cancer Vaccines: Balancing Efficacy an
Whereas conventional manufacturing processes do a
(with exposure to antigens or addition of antigen
Creating new disposables and integrated pieces of
this first clinical study, we want to confirm tha
Advancing Gene-Modified, Inactivated HIV-1 Vaccin
manager of Naobios) told me at the end of 2024, “
With current technologies, today's drug developer
LEVERAGING SPECIALIZED CAPABILITIES With clinical
Geopolitical and socioeconomic factors are likely
CDMOs specializing in AAVs and LVs for gene-thera
Bottlenecks in RNA Delivery Optimization of Lipid
)LJXUH ɄElements of ionizable lipids (LEFT) and c
)LJXUH ɄOverview of adverse events following mRNA
The BENEFITS of mRNA vaccines outweigh the RISKS
Industry Resources HCP Coverage Analysis
Host Cell Protein analysis has never been