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<br /> BioProcess<br /> International<br /> DIGITAL EDITION<br /> ARCHIVE<br /> March 2020 | Volume 18 | Number 3<br /> www.bioprocessintl.com<br /> BioProcess<br /> International<br /> Covering the whole development process<br /> for the global biotechnology industry<br /> DOWNSTREAM<br /> PROCESSING<br /> · Viral Contamination! Now What?<br /> · Lentiviral Vectors for Gene/Cell Therapy<br /> · Digital Outlook: Blockchain and More<br /> · Tracking the Trends in Bioprocessing<br /> · Canada Builds a Biotech Ecosystem<br /> · Where 3D Bioprinting Will Take Us<br /> <br /> We Meet Your Single Use Process<br /> Monitoring Requirements<br /> PendoTECH® In- Line Sensors are<br /> made with USP Class VI materials<br /> and are manufactured in an ISO 13485<br /> facility. They may be gamma irradiated<br /> and are robust enough for extended<br /> re-use. There is no calibration required<br /> and are available in a variety of sizes.<br /> The sensors conn<a title="March 2020 page 1" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=1"> BioProcess International DIGITAL EDITION ARCHIVE</a> <a title="March 2020 page 2" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=2"> March 2020 | Volume 18 | Number 3 www.bioprocessi</a> <a title="March 2020 page 3" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=3"> </a> <a title="March 2020 page 4" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=4"> We Meet Your Single Use Process Monitoring </a> <a title="March 2020 page 5" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=5"> BioProcess International Highlights . . . . . . .</a> <a title="March 2020 page 6" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=6"> </a> <a title="March 2020 page 7" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=7"> MARCH 2020 www.bioprocessintl.com/eBooks Our 202</a> <a title="March 2020 page 8" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=8"> FROM THE EDITOR M y first busines</a> <a title="March 2020 page 9" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=9"> BioProcess Insider The BioProcess Insider digital</a> <a title="March 2020 page 10" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=10"> CHOSOURCETM From lead to manufacture · Identi</a> <a title="March 2020 page 11" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=11"> BPINSIDER Zolgensma (onasemnogene abeparvovec) an</a> <a title="March 2020 page 12" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=12"> BPINSIDER Interpretations: The lack of harmon</a> <a title="March 2020 page 13" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=13"> BPINSIDER “Coronavirus is quite different [from] </a> <a title="March 2020 page 14" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=14"> #CHROMATO GRAPHY EXPERTS SOLUTIONS FOR THE SEP</a> <a title="March 2020 page 15" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=15"> FOCUS ON... INNOVATION New Directions i</a> <a title="March 2020 page 16" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=16"> Figure 1: Investigational new drug (IND) applicat</a> <a title="March 2020 page 17" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=17"> Nonchromatographic purification technology is rec</a> <a title="March 2020 page 18" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=18"> 7 Next-Level Downstream Productivity and</a> <a title="March 2020 page 19" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=19"> FOCUS ON... PRODUCT DEVELOPMENT Scalabl</a> <a title="March 2020 page 20" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=20"> </a> <a title="March 2020 page 21" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=21"> Figure 2: Lentiviral manufacturing process Clos</a> <a title="March 2020 page 22" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=22"> enzyme activity levels, substrate reduction, and </a> <a title="March 2020 page 23" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=23"> FOCUS ON... LOCATION The Next Global Lif</a> <a title="March 2020 page 24" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=24"> Orthogonal HCP Analysis Bioprocess Impurity ELI</a> <a title="March 2020 page 25" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=25"> At the Ottawa Hospital Research Institute, C</a> <a title="March 2020 page 26" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=26"> With collaborative commitment and bold action, Ca</a> <a title="March 2020 page 27" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=27"> BIOPROCESS TECHNICAL A Response Plan for Viral </a> <a title="March 2020 page 28" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=28"> Experience Unrivaled </a> <a title="March 2020 page 29" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=29"> Figure 1: Usually stated in terms of a risk prior</a> <a title="March 2020 page 30" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=30"> </a> <a title="March 2020 page 31" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=31"> Figure 2: The three main phases of a viral-contam</a> <a title="March 2020 page 32" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=32"> Figure 3: Example response flow diagram (swim-lan</a> <a title="March 2020 page 33" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=33"> diamond), virus contamination may or may not be c</a> <a title="March 2020 page 34" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=34"> FUJIFILM Diosynth Biotechnologies is a world lead</a> <a title="March 2020 page 35" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=35"> Timelines can vary greatly from case to case, but</a> <a title="March 2020 page 36" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=36"> Performing routine simulations is a great way to </a> <a title="March 2020 page 37" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=37"> BIOPROCESS TECHNICAL Using Blockchain Technolog</a> <a title="March 2020 page 38" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=38"> Discover, Develop, Deliver... &XVWRP$IÀQLW\$GV</a> <a title="March 2020 page 39" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=39"> and restore functionalities must be established. </a> <a title="March 2020 page 40" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=40"> CLARIFICATION SOLUTION FOR PLASMID DNA Economic </a> <a title="March 2020 page 41" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=41"> distributed as a true copy to each peer of the ch</a> <a title="March 2020 page 42" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=42"> BIOPHARMACEUTICAL ANALYTICAL DEVELOPMENT PROVEN E</a> <a title="March 2020 page 43" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=43"> Figure 2: Error for invalid response such as be</a> <a title="March 2020 page 44" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=44"> As a commercial CDMO, we've increased our Process</a> <a title="March 2020 page 45" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=45"> SUPPLIER SIDE Implementation of Single-Use Minia</a> <a title="March 2020 page 46" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=46"> Figure 1: Viable cell density (VCD) and viability</a> <a title="March 2020 page 47" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=47"> Figure 2: Viable cell density (VCD) and viability</a> <a title="March 2020 page 48" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=48"> 30 days. Additionally, the four quality attribute</a> <a title="March 2020 page 49" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=49"> ASK THE EXPERT Accelerating Developme</a> <a title="March 2020 page 50" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=50"> ASK THE EXPERT mixing conditions in larger biorea</a> <a title="March 2020 page 51" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=51"> ASK THE EXPERT Best Practices for Aseptic Sampli</a> <a title="March 2020 page 52" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=52"> The World's Largest Biotechnology </a> <a title="March 2020 page 53" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=53"> </a> <a title="March 2020 page 54" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=54"> BioProcess International BioProcess Internat</a> <a title="March 2020 page 55" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=55"> THE WORLD'S LARGEST MEETING TO ACCELERATE OLIGONU</a> <a title="March 2020 page 56" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=56"> MAXIMIZE EFFICIENCY You'll find the solutions here</a> <a title="March 2020 page 57" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=57"> </a> <a title="March 2020 page 58" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=58"> ELU·CIDA·TION Better Bioprinting Ahead Breakthrou</a> <a title="March 2020 page 59" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=59"> ELU·CIDA·TION heterogenous microarchitectures, wh</a> <a title="March 2020 page 60" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=60"> THIS IS PROCESS EVOLUTION SciLog® FD System Auto</a> <a title="March 2020 page 61" href="https://secure.viewer.zmags.com/publication/3b43a0a9?page=61"> CREATING BIOLOGIC TREATMENTS IS SCIENCE. 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