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<br /> BioProcess<br /> International<br /> DIGITAL EDITION<br /> ARCHIVE<br /> June 2024 | Volume 22 | Number 6<br /> https://www.bioprocessintl.com<br /> BioProcess<br /> International<br /> Covering the whole development process<br /> for the global biotechnology industry<br /> OUTSOURCING<br /> · Planning, Oversight, and Due Diligence<br /> in Technology Transfer<br /> · Digital Platforms for Collaborative<br /> Research and Development<br /> · Emerging CDMO Partnerships Enable<br /> CGT Success<br /> · India and USA Team Up for Drug<br /> Discovery and Development<br /> · Setting Specs for Cleanroom Ops<br /> · Bioreactor Fluid Flow and Mixing<br /> GMP Production Where<br /> and When You Need It.<br /> CAPABILITIES INCLUDE:<br /> Drug Substance (DS) Manufacture<br /> · 262,000 L bioreactor capacity, expanding to 588,000 L by 2026<br /> · Single-use/disposable bioreactors<br /> · Scale-out manufacturing paradigm<br /> · Fed-batch or <a title="June 2024 page 1" href="https://secure.viewer.zmags.com/publication/2a459369?page=1"> BioProcess International DIGITAL EDITION ARCHIVE</a> <a title="June 2024 page 2" href="https://secure.viewer.zmags.com/publication/2a459369?page=2"> June 2024 | Volume 22 | Number 6 https://www.</a> <a title="June 2024 page 3" href="https://secure.viewer.zmags.com/publication/2a459369?page=3"> GMP Production Where and When You Need It. CAPA</a> <a title="June 2024 page 4" href="https://secure.viewer.zmags.com/publication/2a459369?page=4"> BioProcess International Highlights . . . . . . </a> <a title="June 2024 page 5" href="https://secure.viewer.zmags.com/publication/2a459369?page=5"> JUNE 2024 https://www.bioprocessintl.com/eBooks B</a> <a title="June 2024 page 6" href="https://secure.viewer.zmags.com/publication/2a459369?page=6"> FROM THE EDITOR A s you read</a> <a title="June 2024 page 7" href="https://secure.viewer.zmags.com/publication/2a459369?page=7"> BioProcess Insider The BioProcess Insider portal</a> <a title="June 2024 page 8" href="https://secure.viewer.zmags.com/publication/2a459369?page=8"> ARE YOU LOOKING FOR EXPERTS IN MICROBIAL PRODUC</a> <a title="June 2024 page 9" href="https://secure.viewer.zmags.com/publication/2a459369?page=9"> BPINSIDER efficiency of big pharmaceutical compan</a> <a title="June 2024 page 10" href="https://secure.viewer.zmags.com/publication/2a459369?page=10"> </a> <a title="June 2024 page 11" href="https://secure.viewer.zmags.com/publication/2a459369?page=11"> )2&86ɊON... PROCESS DEVELOPMENT Keys to Suc</a> <a title="June 2024 page 12" href="https://secure.viewer.zmags.com/publication/2a459369?page=12"> monitoring, including reviews, feedback sessions,</a> <a title="June 2024 page 13" href="https://secure.viewer.zmags.com/publication/2a459369?page=13"> The path to SUCCESSFUL technology transfer is muc</a> <a title="June 2024 page 14" href="https://secure.viewer.zmags.com/publication/2a459369?page=14"> Enable better vaccines with TrypsiNNex® Int</a> <a title="June 2024 page 15" href="https://secure.viewer.zmags.com/publication/2a459369?page=15"> )2&86ɊON... BIOPROCESS 4.0 Transforming Bio</a> <a title="June 2024 page 16" href="https://secure.viewer.zmags.com/publication/2a459369?page=16"> real time, irrespective of geography. They can no</a> <a title="June 2024 page 17" href="https://secure.viewer.zmags.com/publication/2a459369?page=17"> Figure 2:ɄAlthough digital collaboration platform</a> <a title="June 2024 page 18" href="https://secure.viewer.zmags.com/publication/2a459369?page=18"> )2&86ɊON... ADVANCED THERAPIES Elevating th</a> <a title="June 2024 page 19" href="https://secure.viewer.zmags.com/publication/2a459369?page=19"> In the next three to five years, the rise of arti</a> <a title="June 2024 page 20" href="https://secure.viewer.zmags.com/publication/2a459369?page=20"> Companies can significantly ENHANCE their talent </a> <a title="June 2024 page 21" href="https://secure.viewer.zmags.com/publication/2a459369?page=21"> )2&86ɊON... BUSINESS US–India Collaborative I</a> <a title="June 2024 page 22" href="https://secure.viewer.zmags.com/publication/2a459369?page=22"> To support those goals, the Indian governmen</a> <a title="June 2024 page 23" href="https://secure.viewer.zmags.com/publication/2a459369?page=23"> the global magnetic resonance imaging (MRI) equip</a> <a title="June 2024 page 24" href="https://secure.viewer.zmags.com/publication/2a459369?page=24"> FIND US AT BOOTH #4649 AT THE BIO INTERNATI</a> <a title="June 2024 page 25" href="https://secure.viewer.zmags.com/publication/2a459369?page=25"> BIOPROCESS TECHNICAL Extending the Visible Resid</a> <a title="June 2024 page 26" href="https://secure.viewer.zmags.com/publication/2a459369?page=26"> 7DEOH ɄFrom three observation angles and lightin</a> <a title="June 2024 page 27" href="https://secure.viewer.zmags.com/publication/2a459369?page=27"> 7DEOH ɄVisible residue limit (VRL) testing of cou</a> <a title="June 2024 page 28" href="https://secure.viewer.zmags.com/publication/2a459369?page=28"> Continuing to lead the way in RNA manufacturing </a> <a title="June 2024 page 29" href="https://secure.viewer.zmags.com/publication/2a459369?page=29"> 7DEOH ɄSummary of results from visible residue li</a> <a title="June 2024 page 30" href="https://secure.viewer.zmags.com/publication/2a459369?page=30"> Our results were similar for coupons spotte</a> <a title="June 2024 page 31" href="https://secure.viewer.zmags.com/publication/2a459369?page=31"> BIOPROCESS TECHNICAL Establishing a Life Cycle f</a> <a title="June 2024 page 32" href="https://secure.viewer.zmags.com/publication/2a459369?page=32"> particles, such as those that carry microorganism</a> <a title="June 2024 page 33" href="https://secure.viewer.zmags.com/publication/2a459369?page=33"> 7DEOH ɄPore size results Sample Reference </a> <a title="June 2024 page 34" href="https://secure.viewer.zmags.com/publication/2a459369?page=34"> preparation. However, the observed particle count</a> <a title="June 2024 page 35" href="https://secure.viewer.zmags.com/publication/2a459369?page=35"> BIOPROCESS TECHNICAL Lessons in Bioreactor Scale</a> <a title="June 2024 page 36" href="https://secure.viewer.zmags.com/publication/2a459369?page=36"> 7DEOH ɄComparison of parameters used for calculat</a> <a title="June 2024 page 37" href="https://secure.viewer.zmags.com/publication/2a459369?page=37"> )LJXUH ɄPitched-blade and paddle (Rushton) impell</a> <a title="June 2024 page 38" href="https://secure.viewer.zmags.com/publication/2a459369?page=38"> 7KHUH·VÀUVWWKHQWKHUH·VHYHU\RQHHOVH ,QVXFK</a> <a title="June 2024 page 39" href="https://secure.viewer.zmags.com/publication/2a459369?page=39"> )LJXUH ɄThe radial flow pattern induced by Rushto</a> <a title="June 2024 page 40" href="https://secure.viewer.zmags.com/publication/2a459369?page=40"> That fluid stream gets divided in half, with one </a> <a title="June 2024 page 41" href="https://secure.viewer.zmags.com/publication/2a459369?page=41"> )LJXUH ɄMixing times measured in a 400-L stirred </a> <a title="June 2024 page 42" href="https://secure.viewer.zmags.com/publication/2a459369?page=42"> </a> <a title="June 2024 page 43" href="https://secure.viewer.zmags.com/publication/2a459369?page=43"> REFERENCES Note: To refer back to part 1, </a> <a title="June 2024 page 44" href="https://secure.viewer.zmags.com/publication/2a459369?page=44"> SUPPLIER SIDE High Aggregate Levels with Enginee</a> <a title="June 2024 page 45" href="https://secure.viewer.zmags.com/publication/2a459369?page=45"> )LJXUH ɄTypical operating ranges for intermediate</a> <a title="June 2024 page 46" href="https://secure.viewer.zmags.com/publication/2a459369?page=46"> 7DEOH ɄHost-cell protein (HCP) classification and</a> <a title="June 2024 page 47" href="https://secure.viewer.zmags.com/publication/2a459369?page=47"> ASK THE EXPERT Turning Biologic Innovation into </a> <a title="June 2024 page 48" href="https://secure.viewer.zmags.com/publication/2a459369?page=48"> and filings all meet stringent regulatory standar</a> <a title="June 2024 page 49" href="https://secure.viewer.zmags.com/publication/2a459369?page=49"> ASK THE EXPERT Moving Towards Scalable AAV</a> <a title="June 2024 page 50" href="https://secure.viewer.zmags.com/publication/2a459369?page=50"> scientists ran and analyzed two culture processes</a> <a title="June 2024 page 51" href="https://secure.viewer.zmags.com/publication/2a459369?page=51"> ELU·CIDA·TION Artificial Intelligence Overdrive </a> <a title="June 2024 page 52" href="https://secure.viewer.zmags.com/publication/2a459369?page=52"> </a> <a title="June 2024 page 53" href="https://secure.viewer.zmags.com/publication/2a459369?page=53"> Automated Cell Culture Analyzers Test menus speci</a>