<br />
BioProcess<br />
International<br />
DIGITAL EDITION<br />
ARCHIVE<br />
Upstream:<br />
Make the right decisions for your mAb<br />
Upstream strategies to ·<br />
lay the groundwork for ·<br />
downstream success:<br />
·<br />
·<br />
Robust cell line selection for high titer<br />
Specifically-designed platform medium<br />
for intensified upstream<br />
Mixing and delivery solutions<br />
for efficient media preparation<br />
Testing approaches to characterize<br />
effector function<br />
TAKE THE<br />
RIGHT PATH<br />
UPSTREAM<br />
You are developing a monoclonal antibody and a world of<br />
potential is ahead of you. However, your time to realize this potential<br />
is limited. You need to act quickly to get your biological drug to<br />
market, but have you considered the impact of your decisions as<br />
you are developing upstream? Decisions may be difficult to reverse<br />
or w<a title="January/February 2020 - Millipore Sigma page 1" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=1"> BioProcess International DIGITAL EDITION ARCHIVE</a>
<a title="January/February 2020 - Millipore Sigma page 2" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=2"> Upstream: Make the right decisions for your mAb U</a>
<a title="January/February 2020 - Millipore Sigma page 3" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=3"> TAKE THE RIGHT PATH UPSTREAM You are developing a</a>
<a title="January/February 2020 - Millipore Sigma page 4" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=4"> Time Is of the Essence Optimizing Cell Line Devel</a>
<a title="January/February 2020 - Millipore Sigma page 5" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=5"> include a signal peptide that mediates translocat</a>
<a title="January/February 2020 - Millipore Sigma page 6" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=6"> Figure 3: Comprehensive cell line development ser</a>
<a title="January/February 2020 - Millipore Sigma page 7" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=7"> · Perform second transfection using the same</a>
<a title="January/February 2020 - Millipore Sigma page 8" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=8"> The Critical Role of Media in Intensified Upstrea</a>
<a title="January/February 2020 - Millipore Sigma page 9" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=9"> based on a foundational platform effectively dire</a>
<a title="January/February 2020 - Millipore Sigma page 10" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=10"> Figure 3: IgG production is increased with use of</a>
<a title="January/February 2020 - Millipore Sigma page 11" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=11"> Innovative Strategies for Cell Culture Media Prep</a>
<a title="January/February 2020 - Millipore Sigma page 12" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=12"> Figure 2: Use of the EZ BioPac transfer bag and </a>
<a title="January/February 2020 - Millipore Sigma page 13" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=13"> · offers permanent antistatic formulation, w</a>
<a title="January/February 2020 - Millipore Sigma page 14" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=14"> Mitigate Risk with Effector Function Characteriza</a>
<a title="January/February 2020 - Millipore Sigma page 15" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=15"> regarding likely effector functionality can be cr</a>
<a title="January/February 2020 - Millipore Sigma page 16" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=16"> ADC Effector Characterization Understanding effe</a>
<a title="January/February 2020 - Millipore Sigma page 17" href="https://secure.viewer.zmags.com/publication/0c0420a2?page=17"> Intensify and Evolve. Together. Explore The BioC</a>