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FEATURED REPORT
BioProcess
International
Vaccines and
Viral Vectors
The Intersection of
Immunology and Innovation
FEBRUARY 2026
C2 Vaccines on Defense 02 Rapid Vaccine Development
Cheryl Scott Lee Smith
05 The Forgotten 40 Million
David Dodd
09 Perspectives on the Use of AI/ML Methodologies in
Vaccine Development
Luke 2ȇ.eee
13 What Replaces Animal Models?
Subash Das and Lee Smith
17 Tools for AAV Capsid-Content
Characterization
Ray Zhang and Patrick Lehman
24 Engineering Outer-Membrane Vesicles
Chen Dong, Miki Lee, Qiubin Lin,
and Jason He
26 Critical Needs for Animal-Vaccine
Manufacturing
Brian Gazaille and Sarah Stefancin,
with Gustavo Mendes
29 Resources<
FEATURED REPORT BioProcess International Vacci
Introduction Vaccines on Defense Cheryl Scott W
approaches in preclinical development, but it als
Rapid Vaccine Development COVID-19 Lessons and Fu
work, with efforts underway to improve the thermo
thus building public confidence that safety isn't
The Forgotten 40 Million Immunocompromised Americ
A STRUCTURAL FAILURE, NOT AN OVERSIGHT Such exclu
REDESIGNING BIOTECHNOLOGY FOR THE VULNERABLE Rect
10 Booth CM, et al. Real-World Data: Toward
Perspectives on Artificial Intelligence and Machi
(PD-1) checkpoint inhibitor developed by Merck an
sequences that are integrated within vertebrate g
Although large language models are SHAPED by the
Animal Models and Beyond — What's Next? A Preclin
Although animals undeniably have played a pivotal
immune responses, viral tropism, and mucosal inte
approaches (8). International initiatives such as
Tools for AAV Capsid-Content Characterization Com
7DEOH ɄParameters assigned in DiscoverMP software
)LJXUH ɄReplicate-overlayed distribution plots fr
)LJXUH ɄComparing percentages of (A) empty, (B) p
Figure 3: Pearson correlation heatmap for dataset
)LJXUH ɄBland–Altman analysis plotting the differ
Table 4: Results of the Wilcoxon equivalence test
Engineering Outer-Membrane Vesicles Leverage Rati
As the pipeline continues EXPANDING, gOMV-based p
Critical Needs for Animal-Vaccine Manufacturing A
formulation. Additionally, the US Department of A
same type of vaccine. For example, imagine two co
Industry Resources 2D Cell Culture Cornin